Endocrine Abstracts

Objective: The risk of aortic dissection is 100-fold increased in Turner syndrome (TS). Increased blood pressure (BP) and heart rate is present as well as an increased risk of ischemic heart disease and diabetes. This study aimed to prospectively assess heart rate variability (HRV) in TS and its relation to aortic dimensions.Methods: Adults with TS (n=91, aged 37.4±10.4 years) recruited through the Danish National Society of Turner Syndrome...

Background: Aortic dissection causes excess mortality in Turner syndrome, and this increased risk is associated with aortic dilation, congenital cardiovascular abnormalities, karyotype, and blood pressure. But risk factor identification is inadequate, and the natural course of aortopathy in Turner syndrome is poorly investigated.Design and methods: Prospective follow-up study in women with Turner syndrome (n=102, examined twice) and healthy age-ma...

Objective: QT interval prolongation of unknown aetiology is common in Turner syndrome (TS). This study set out to explore the presence of known pathogenic long QT (LQT) mutations in TS and to examine the corrected QT interval (QTc) over time and relate the findings to the TS phenotype.Methods: Adult females with TS (n=102) were examined thrice with a mean follow-up of 4.7±0.5 years, and 68 age-matched healthy controls were examined once. QT...